Publications by authors named "M Guizzardi"
We introduce a family of membrane-targeted azobenzenes (MTs) with a push-pull character as a new tool for cell stimulation. These molecules are water soluble and spontaneously partition in the cell membrane. Upon light irradiation, they isomerize from trans to cis, changing the local charge distribution and thus stimulating the cell response.
View Article and Find Full Text PDFThis study investigates the use of near-infrared fluorescence imaging (NIFI) as an alternative to intraoperative parathyroid hormone (ioPTH) measurement in patients with primary hyperparathyroidism (PHP) due to parathyroid adenoma (PA) with two preoperative imaging examinations in agreement on the position of the altered parathyroid gland. Fifty patients who underwent minimally invasive parathyroidectomy (MIP) from March 2021 to April 2024 were enrolled. MIPs utilised both NIFI and ioPTH, comparing the time to adenoma excision with NIFI against the total surgical time, including ioPTH measurement wait time.
View Article and Find Full Text PDFArticle Synopsis
- Metalloporphyrins with open-shell transition metals like Ni(II) have a fast excited-state relaxation mechanism, which is explored in a nanographene-Ni(II) porphyrin conjugate.
- Using variable temperature transient absorption and global fit analysis, the study reveals that after photoexcitation, vibrational cooling occurs in 1.6 ps, followed by a brief 20 ps window where some excited states decay radiatively before intersystem crossing.
- At low temperatures, two relaxation pathways from the lowest triplet state to the ground state are identified: a slow process over 1.6 ns and a faster route influenced by a conical intersection, important for applications in energy harvesting and optoelectronics.
Objective: Approximately 30 % of thyroid nodules yield an indeterminate diagnosis through conventional diagnostic strategies. The aim of this study was to develop machine learning (ML) models capable of identifying papillary thyroid carcinomas using preoperative variables.
Methods: Patients with thyroid nodules undergoing thyroid surgery were enrolled in a retrospective monocentric study.