Detection sensitivity of lymph nodes of various sizes using USPIO nanoparticles in magnetic resonance imaging.

Unlabelled: Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles-based magnetic resonance imaging (MRI) have offered new promise for early detection of lymph nodes and their metastases. These nanoparticles are taken up by macrophages in normal lymph nodes and produce signal changes based on susceptibility artifact and dipolar relaxation. The effects of MR protocols and their parameters on artifact size and detection sensitivity have been studied before.

MR relaxivity measurement of iron oxide nano-particles for MR lymphography applications.

The aim of this study was to assess the T1, T2 and T2* relaxivity of Ultrasmall Super Paramagnetic Iron Oxide (USPIO) nano-particles in vitro and in vivo in rat models with magnetic resonance imaging at 1.5T. First, relaxation properties of USPIO nano-particles at different doses were measured using related SE and GRE MR imaging protocols.

Computer-aided mass detection on digitized mammograms using adaptive thresholding and fuzzy entropy.

In this paper, a segmentation method for detection of masses in digitized mammograms has been developed using two parallel approaches: adaptive thresholding method and fuzzy entropy feature as a CAD scheme. The algorithm consists of the following steps: a) Preprocessing of the digitized mammograms including identification of region of interest (ROI) as candidate for massive lesion through breast region extraction, b) Image enhancement using linear transformation and subtracting enhanced from the original image, c) Characterization of the ROI by extracting the fuzzy entropy feature, d) Local adaptive thresholding for segmentation of mass areas, e) Combine expert of the last two parallel approaches for mass detection. The proposed method was tested on 78 mammograms (30 normal & 48 cancerous) from the BIRADS and local databases.

Detection sensitivity of MRI using ultra-small super paramagnetic iron oxide nano-particles (USPIO) in biological tissues.

Today, by injecting iron oxide based nanoparticles (USPIO) as MRI contrast agents, it is possible to study lymphatic system and some specific tumors and their metastasis. The type of surface coating, and coating characteristics of the nanoparticles are important factors for the biological properties of nanoparticles and their destination target. On the other hand, these properties contribute to different signal intensities.