Publications by authors named "M Guichaoua"
Article Synopsis
- After two meiotic divisions, haploid spermatids undergo significant changes to become mature spermatozoa, which includes compacting the cell nucleus to enhance hydrodynamic properties and protect DNA from oxidative stress during reproduction.
- A study focused on an infertile subject revealed a genetic defect linked to abnormal sperm with large heads due to uncondensed nuclear DNA, specifically identifying a variant in the NUP210L gene that affects sperm development.
- The absence of the NUP210L protein in the patient’s sperm suggests its crucial role in male fertility, as mutations in this gene are associated with reduced sperm count and motility in mouse models, highlighting its potential importance in the diagnosis and treatment of male infertility.
Article Synopsis
- A study of 17 men with decapitated spermatozoa indicated that loss of function of the SUN5 gene is linked to a condition called acephalic spermatozoa syndrome, particularly in men carrying two rare genetic variants.
- While SUN5 normally helps connect the sperm's head and tail, most variants identified were of uncertain impact, and conclusive proof of SUN5 loss leading to the syndrome is still needed.
- Further investigation of three related North African men revealed a specific deletion-insertion variant in SUN5 that disrupts its function, reinforcing the role of SUN5 in male fertility and sperm development.
To measure the testicular toxicity of two fungicides (carbendazim and iprodione), alone or in a mixture, we used a rat ex vivo model of seminiferous tubules, greatly reducing the number of rodents used, in accordance with the 3R rule (Replacement, Reduction, and Refinement). This model allows the representation of puberty, a critical life period with regard to endocrine disruptors. The cellular modifications were followed for three weeks through transcriptomic and proteomic profiling analysis.
View Article and Find Full Text PDFStudies suggest a relationship between semen quality and the concentration of trace elements in serum or seminal plasma. However, trace elements may be linked to DNA and capable of altering the gene expression patterns. Thus, trace element interactions with DNA may contribute to the mechanisms for a trans-generational reproductive effect.
View Article and Find Full Text PDFBackground: Bisphenol A (BPA) is one of the most widespread chemicals in the world and is suspected of being responsible for male reproductive impairments. Nevertheless, its molecular mode of action on spermatogenesis is unclear. This work combines physiology and toxicogenomics to identify mechanisms by which BPA affects the timing of meiosis and induces germ-cell abnormalities.
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