Publications by authors named "M Guazzi"
Article Synopsis
- Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with unknown causes, linked to vascular abnormalities and complications like pulmonary hypertension (PH).*
- A literature review reveals crucial molecular mechanisms involved in vascular changes related to IPF, emphasizing their potential as prognostic markers and highlighting the impact of antifibrotic therapies.*
- The findings suggest that the vasculature is integral to IPF's progression and that emerging treatments with a vascular focus may improve outcomes for patients.*
Aim: We sought the cardiopulmonary exercise testing (CPET) parameter that most accurately reflected therapeutic efficacy in patients with hypertrophic cardiomyopathy (HCM).
Methods: Well-being questionnaire, N-terminal brain natriuretic peptide measurements, echocardiography, and CPET were performed in patients with symptomatic non-obstructive HCM during phase II, randomized, open-label multicentre study, before and after 16 weeks of traditional or sacubitril/valsartan treatment. Patients were followed 36 months after the initial CPET.
Article Synopsis
- * Analyzed data from 7948 HF patients over a minimum of 2 years, employing topological data analysis (TDA) to find 19 patient clusters and trajectory analysis to outline disease evolution.
- * Findings included a 5-year survival rate across clusters ranging from 20% to 100%, with strong validation results from external and internal cohorts, confirming the reliability of the identified patient pathways.