Publications by authors named "M Guan"
Natural disasters can severely disrupt conventional communication systems, hampering relief efforts. High-altitude tethered balloon base stations (HATBBSs) are a promising solution to communication disruptions, providing wide communication coverage in disaster-stricken areas. However, a single HATBBS is insufficient for large disaster zones, and limited resources may restrict the number and energy capacity of available base stations.
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- Elevated lactate levels are linked to serious health issues, including sepsis and mitochondrial dysfunction, and poor lactate clearance can lead to worse outcomes in these conditions.
- Current methods for managing elevated lactate are limited, but recent findings highlight the gut's role in lactate regulation, suggesting a potential link between gut bacteria and blood lactate levels.
- This study presents a promising approach using engineered probiotic spores to deliver lactate oxidase to the gut, which successfully lowers blood lactate in mice without harming gut health or immune function.
Objective: Pulmonary sarcomatoid carcinoma (PSC) is a rare, heterogeneous subgroup of non-small cell lung cancer (NSCLC). Patients with advanced PSCs have poor survival due to resistance to chemotherapy and radiotherapy, and narrow access to targeted therapy. Immune checkpoint inhibitors (ICIs) offer new hope, whereas data on their effectiveness is limited.
View Article and Find Full Text PDFIn this work, a switchable synthesis of β-ketosulfone and α-chloroketone through a radical difunctionalization of alkenes is reported. The transformation works well under iron peroxo species/photoredox dual catalysis and an open-flask atmosphere, and the reaction is highlighted with good yields and a broad reaction scope. Mechanism studies show that the reaction is initiated by a formal [4 + 2] cyclization of the sulfonyl radical in a regioselective manner.
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