Publications by authors named "M Grundbichler"
Background: Pancreatic carcinoma carries a devastating prognosis and is the 4th leading cause for cancer related death in the US and most European countries. Apart from imaging and CA 19-9, pancreatic carcinoma is still lacking reliable markers to assess tumor dynamics and to monitor treatment response over time. The aim of this study was to evaluate the feasibility of cell free tumor-DNA (cft-DNA), respectively KRAS mutation in peripheral blood, detection as a prognostic and predictive value for chemotherapy monitoring.
View Article and Find Full Text PDFArticle Synopsis
- * The majority of patients are middle-aged (median age 34 years), with 39% having severe haemophilia, and there are notable health concerns as 38.4% of those with severe cases have HCV and 12.6% have HIV.
- * Treatment approaches show that 68.4% of patients with severe haemophilia are on prophylactic therapy, with many using recombinant products, highlighting ongoing challenges with infections and treatment strategies in this population. *
Cytomegalovirus reactivation can be life threatening. However, little evidence on its incidence in solid cancers is available. Therefore our single center Cytomegalovirus polymerase chain reaction database with altogether 890 CMV positive blood serum samples of mainly hematological and oncological patients was retrospectively analyzed to examine the occurrence of Cytomegalovirus reactivation in patients with solid tumors, resulting in 107 patients tested positive for Cytomegalovirus reactivation.
View Article and Find Full Text PDFIn haemophilia A patients factor VIII (FVIII) recovery and half-life can vary substantially. There are parameters known to modulate FVIII pharmacokinetics (PK), but they explain only about 34% of the variability. The aim of this study was to identify new parameters that influence FVIII PK and thus to expand the current knowledge.
View Article and Find Full Text PDFLiver toxicity during temozolomide chemotherapy caused by Chinese herbs.
BMC Complement Altern Med
March 2014
Background: Complementary and alternative medicine is often used by patients with malignant glioma. Although several interactions of various alternative agents with chemotherapy are known, none has been described for temozolomide so far.
Case Presentation: We report the case of severe liver toxicity with jaundice during radiochemotherapy with temozolomide likely due to interaction with a popular Chinese herbal formula after surgery for glioblastoma.