Publications by authors named "M Gruchala"
Oxidative modifications of lipoproteins play a crucial role in the initiation of atherosclerotic cardiovascular diseases (ASCVDs). Nowadays, the one effective strategy for the treatment of patients with hyperlipoproteinemia(a) is lipoprotein apheresis (LA), which has a pleiotropic effect on reducing the risk of ASCVDs. The significance of oxidative susceptibility of the LDL fraction in ASCVDs has been extensively studied.
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- - Mitral regurgitation (MR) is the second most common heart valve disease, and severe cases often require surgical intervention, though high-risk patients may need alternative treatments like transcatheter edge-to-edge valve repair or the Tendyne valve.
- - The Tendyne valve, which can be implanted without traditional surgery, showed promising results: 93.2% of patients had no MR after treatment, and heart failure hospitalizations significantly decreased post-surgery.
- - An economic analysis indicated that using the Tendyne valve is cost-effective compared to medications, with a favorable cost per quality-adjusted life year, and around 60 patients annually could benefit from this treatment in Poland.
The diagnosis of end-stage renal disease (ESRD) is made when the estimated glomerular filtration rate is less than 15 mL/min/1.73 m2. Most patients with that stage of chronic kidney disease (CKD) are eligible for renal replacement treatment, which includes kidney transplantation, hemodialysis and peritoneal dialysis.
View Article and Find Full Text PDFHypercholesterolemia-associated oxidative stress increases the formation of oxidized low-density lipoprotein (oxLDL), which can affect endothelial cell function and potentially contribute to renal dysfunction, as reflected by changes in urinary protein excretion. This study aimed to investigate the impact of exogenous oxLDL on urinary excretion of albumin and nephrin. LDL was isolated from a patient with familial hypercholesterolemia (FH) undergoing lipoprotein apheresis (LA) and was oxidized in vitro with Cu (II) ions.
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