Publications by authors named "M Grove"
The relationship between mitochondrial DNA (mtDNA) heteroplasmy and nuclear DNA (nDNA) methylation (CpGs) remains to be studied. We conducted an epigenome-wide association analysis of heteroplasmy burden scores across 10,986 participants (mean age 77, 63% women, and 54% non-White races/ethnicities) from seven population-based observational cohorts. We identified 412 CpGs (FDR p < 0.
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- * The study shows that heteroplasmy is more prevalent in people with clonal hematopoiesis, especially when there are multiple mutations or certain types of mutations present.
- * Including heteroplasmy in risk assessment models enhances the ability to identify high-risk individuals for myeloid neoplasms, indicating its potential as a significant biomarker for these conditions.
Article Synopsis
- Circulating metabolite levels are indicators of human health and can be influenced by genetic factors; however, most research has focused on European populations.
- The study utilized metabolomics data from 25,058 diverse individuals, identifying 1,778 gene loci linked to 667 metabolites and providing methods for data analysis and handling.
- Notably, the research uncovered new genetic associations, including 108 novel gene-metabolite pairs, and highlighted sex differences in metabolism, enhancing the understanding of genetic influences on human health.
Article Synopsis
- Neurofibromatosis type 2 (NF2) is a rare condition leading to tumors like vestibular schwannomas and meningiomas, and currently lacks FDA approved medication.* -
- Previous research shows that BET inhibition can slow the growth of NF2-related cells, and this study investigates whether combining both BET and FAK inhibition could enhance these effects.* -
- Results indicate that this combination effectively halts the growth of NF2-null cells by disrupting their cell cycle and significantly downregulating FAK1, suggesting a promising new treatment approach for NF2-related tumors.*
Article Synopsis
- - Autism spectrum disorder (ASD) is a complex condition influenced by genetic and environmental factors, but its connection with metabolic changes is not well understood.
- - A study analyzed plasma samples from 200 children with ASD and 200 typically developing controls to discover specific metabolites that could serve as biomarkers for the disorder.
- - The research found distinct metabolic patterns in ASD children, identifying four significant metabolites, including three fatty acids and the amino acid sarcosine, which may inform future interventions for ASD.