Publications by authors named "M Gritter"
5/6 Nephrectomy impairs acute kaliuretic responses and predisposes to postprandial hyperkalemia.
Am J Physiol Renal Physiol
December 2024
The susceptibility of patients with chronic kidney disease to develop postprandial hyperkalemia suggests alterations in normal kidney sodium (Na) and potassium (K) handling, but the exact nature of these changes is largely unknown. To address this, we analyzed the natriuretic and kaliuretic responses to diuretics and acute K loading in rats who underwent 5/6 nephrectomy (5/6Nx) and compared this with the response in sham-operated rats. The natriuretic and kaliuretic responses to furosemide, hydrochlorothiazide, and amiloride were largely similar between 5/6Nx and sham rats except for a significantly reduced kaliuretic response to hydrochlorothiazide in 5/6Nx rats.
View Article and Find Full Text PDFArticle Synopsis
- Dietary potassium (K+) plays a role in heart and kidney health, but its effects on those with chronic kidney disease (CKD) are uncertain; this study suggests CKD may heighten vulnerability to both low and high potassium diets.
- In experiments with male rats, those with CKD on a low potassium chloride (KCl) diet experienced significant kidney injury and inflammation, while those on a high KCl diet developed severe hypertension and other metabolic issues not seen in healthy rats.
- The study found that a high potassium citrate diet reduced hypertension effects but did not completely prevent kidney damage, highlighting that CKD makes kidneys more sensitive to potassium levels and their related complications.
Background: A potassium replete diet is associated with lower cardiovascular risk but may increase the risk of hyperkalemia, particularly in people using renin-angiotensin-aldosterone system inhibitors. We investigated whether intracellular uptake and potassium excretion after an acute oral potassium load depend on the accompanying anion and/or aldosterone and whether this results in altered plasma potassium change.
Methods: In this placebo-controlled interventional cross-over trial including 18 healthy individuals, we studied the acute effects of one oral load of potassium citrate (40 mmol), potassium chloride (40 mmol), and placebo in random order after overnight fasting.
Background: Hyperkalemia is an electrolyte disorder requiring medical attention because it can cause cardiac arrhythmias. Pseudohyperkalemia is the phenomenon of an elevated potassium concentration that is present in the blood sample but not in the patient. Pseudohyperkalemia can be caused by hemolysis, leukocytosis, thrombocytosis, seasonal pseudohyperkalemia, potassium release from muscle cells due to fist clenching during venipuncture, and contamination due to blood withdrawal from an intravenous line over which potassium was administered.
View Article and Find Full Text PDF