Publications by authors named "M Grimaud"
Objectives: Children on extracorporeal membrane oxygenation (ECMO) are at high risk of infection that may worsen prognosis. Even though treatment with beta-lactam antibiotics is frequent, dosing is not adapted to altered pharmacokinetic and pharmacodynamic characteristics of children on ECMO. There is, therefore, a risk of inadequate drug levels when using standard dosing.
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- Children with cystic fibrosis (CF) often face acute respiratory failure due to severe pulmonary exacerbations, leading to pediatric intensive care unit (PICU) admissions, with a focus on understanding their short and medium-term outcomes.
- A study reviewed data from patients under 18 years old admitted to a French PICU over two decades, utilizing statistical methods to identify factors influencing mortality and the need for lung transplants.
- Results indicated high mortality rates (up to 41% within 3 years post-discharge) and identified key risk factors like gender, certain blood gas levels, and pre-admission health conditions, highlighting the critical need for early consideration of lung transplants as a survival option.
One of the major hurdles that has hindered the success of chimeric antigen receptor (CAR) T cell therapies against solid tumors is on-target off-tumor (OTOT) toxicity due to sharing of the same epitopes on normal tissues. To elevate the safety profile of CAR-T cells, an affinity/avidity fine-tuned CAR was designed enabling CAR-T cell activation only in the presence of a highly expressed tumor associated antigen (TAA) but not when recognizing the same antigen at a physiological level on healthy cells. Using direct stochastic optical reconstruction microscopy (dSTORM) which provides single-molecule resolution, and flow cytometry, we identified high carbonic anhydrase IX (CAIX) density on clear cell renal cell carcinoma (ccRCC) patient samples and low-density expression on healthy bile duct tissues.
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- ECMO usage in children is linked to brain injuries, but its effects on long-term neurologic development and quality of life are not well understood.
- This study assessed outcomes in 40 ECMO survivors from Necker Children's Hospital, evaluating neurologic status, and health-related quality of life through parent and patient interviews.
- At follow-up, most patients showed good overall quality of life, with a significant portion demonstrating normal developmental scores, suggesting that severe long-term disabilities were uncommon in this group.
To assess the feelings and knowledge of health care professionals (HCPs) about gasping in dying patients in neonatal intensive care units (NICUs) and pediatric intensive care units (PICUs). A 9-item questionnaire addressed to 488 HCPs (physicians, nurses, and nursing assistants) of 2 NICUs and 2 PICUs. Questions were about HCPs' feelings when confronted with gasping, their knowledge, and their opinions on what to tell family members.
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