Postinfectious bronchiolitis obliterans in children: clinical and pulmonary function findings.

Aim: Postinfectious bronchiolitis obliterans (PIBO) is an infrequent yet potentially severe disorder following acute lower pulmonary infection (ALRI) in children. In infants and young children PIBO have been strongly associated with Adenovirus (Ad). The purpose of this study was to analyze the clinical features and pulmonary function findings in children with PIBO.

[Factors related to the approval, development and publication of research protocols in a paediatric hospital].

Background: Unpublished research is a frequent and reported problem. Objective. To analyze factors associated to approval, development and publication of research protocols submitted to Hospital Garrahan Institutional Review Board.

Influence of beta2-adrenoceptor polymorphisms on the response to chronic use of albuterol in asthmatic children.

Background: Several studies have suggested that after regular use of short acting beta2-agonists the bronchodilator effect of the drug may decline and this condition would be related to polymorphisms of the beta2-adrenergic receptor (beta2-AR).

Objective: To assess the frequency of beta2-AR polymorphisms in asthmatic children from Argentina, and to evaluate their influence on bronchodilator desensitization to albuterol over a 4-week treatment.

Methods: beta2-AR genotypes were determined in 117 children with asthma and 101 of them were under 4 weeks treatment with albuterol.