Publications by authors named "M Gregor"
Limited validity of Mayo endoscopic subscore in ulcerative colitis with concomitant primary sclerosing cholangitis.
World J Gastrointest Endosc
November 2024
Background: Ulcerative colitis (UC) with concomitant primary sclerosing cholangitis (PSC) represents a distinct disease entity (PSC-UC). Mayo endoscopic subscore (MES) is a standard tool for assessing disease activity in UC but its relevance in PSC-UC remains unclear.
Aim: To assess the accuracy of MES in UC and PSC-UC patients, we performed histological scoring using Nancy histological index (NHI).
Article Synopsis
- Glioblastoma is the most common and aggressive primary brain tumor, making diagnosis difficult due to its genetic variability and poor prognosis.
- A complex case study utilized multiple cytogenomic methods to identify key genetic markers, revealing classical glioblastoma characteristics and distinct pathological clones.
- The study suggests an integrated approach for diagnosis, focusing on detecting genetic alterations to potentially improve patient outcomes in terms of diagnosis, prognosis, and treatment predictions.
Biodielectrics: old wine in a new bottle?
Front Bioeng Biotechnol
October 2024
Biodielectrics is a subset of biological and/or bioinspired materials that has brought a huge transformation in the advancement of medical science, such as localized drug delivery in cancer therapeutics, health monitoring, bone and nerve repair, tissue engineering and use in other nanoelectromechanical systems (NEMS). While biodielectrics has long been used in the field of electrical insulation for over a century, polar dielectric properties of biological building blocks have not been well understood at the fundamental building block level. In this review article, we provide a brief overview of dielectric properties of biological building blocks and its hierarchical organisations to include polar dielectric properties such as piezo, pyro, and ferroelectricity.
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- Super-resolution microscopy provides high-detail imaging but faces challenges with thick biological specimens, such as oocytes.
- Optimizing sample preparation is crucial for achieving optical clarity, which enhances imaging capabilities for larger structures.
- This study introduces a new method involving alcohol dehydration and high-refractive-index mounting, allowing for successful 3D imaging of mouse oocytes, thereby improving the analysis of complex biological processes.
Article Synopsis
- Fibrosis plays a role in healing but excessive fibrosis harms organ function, particularly in Alagille syndrome (ALGS), which is linked to mutations in the JAGGED1 gene that can lead to liver disease and fibrosis.
- Research using Jag1 mice, a model for ALGS, demonstrated unusual liver characteristics, including immature liver cells and surprisingly few T cells, despite cholestasis (bile flow blockage).
- The study also showed that when regulatory T cells were transferred to Rag1 mice, they led to less inflammation and fibrosis in response to liver damage, indicating that both hepatic and immune system flaws contribute to the fibrotic issues seen in ALGS.