Publications by authors named "M Gravina"
Aims: While factors associated with adverse events are well elucidated in setting of isolated left ventricular dysfunction, clinical and imaging-based prognosticators of adverse outcomes are lacking in context of biventricular dysfunction. The purpose of this study was to establish role of clinical variables in prognosis of biventricular heart failure (HF), as assessed by cardiac magnetic resonance imaging.
Methods: Study cohort consisted of 840 patients enrolled in DERIVATE registry with coexisting CMR-derived right ventricular (RV) and left ventricular (LV) dysfunction, as defined by RV and LV ejection fractions ≤45 % and ≤ 50 %, respectively.
Marine bioconstructions and their ecological functions are increasingly threatened by compounded natural disturbances and direct and indirect impacts of anthropogenic activities. Through a manipulative experiment in the field, we assessed the response of intertidal biogenic patches built by the honeycomb worm, Sabellaria alveolata, to combined disturbances. Repeated battering events, simulating those associated with waves, were applied on intact or previously damaged bioconstructions, mimicking those impacted by harvesting of infaunal organisms.
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- Anderson-Fabry disease (AFD) is a rare genetic disorder that leads to organ damage due to a lack of α-galactosidase A, causing harmful substances to accumulate in tissues, particularly affecting the heart and kidneys.
- * Researchers conducted a study using cardiovascular magnetic resonance (CMR) and T1 mapping to evaluate kidney involvement in 19 AFD patients compared to a control group without kidney disease.
- * The findings indicated a positive correlation between heart and kidney T1 values in AFD patients, and a negative correlation in kidney T1 values between AFD and control patients, suggesting kidney damage from microvascular issues in AFD.
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- ECP is a promising treatment for managing acute rejection in heart transplant patients by modulating the immune system, particularly through the action of regulatory T cells (Treg).
- The study involved 14 heart transplant participants undergoing ECP therapy, assessing the effects on Treg frequency and their suppressive functions over time, alongside a control group.
- Results indicate that ECP significantly boosts the number and function of suppressive Tregs, particularly those marked by the transcription factor FoxP3, which helps control immune responses and prevent graft rejection.
In the field of veterinary medicine, the detection of parasite eggs in the fecal samples of livestock animals represents one of the most challenging tasks, since their spread and diffusion may lead to severe clinical disease. Nowadays, the scanning procedure is typically performed by physicians with professional microscopes and requires a significant amount of time, domain knowledge, and resources. The Kubic FLOTAC Microscope (KFM) is a compact, low-cost, portable digital microscope that can autonomously analyze fecal specimens for parasites and hosts in both field and laboratory settings.
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