Publications by authors named "M Gratton"
Alterations in mitochondrial function are the linchpin in numerous disease states including in the development of chemotherapy-induced neuropathic pain (CIPN), a major dose-limiting toxicity of widely used chemotherapeutic cytotoxins. In CIPN, mitochondrial dysfunction is characterized by deficits in mitochondrial bioenergetics (e.g.
View Article and Find Full Text PDFBackground: Monitoring toxicities among patients receiving immune checkpoint inhibitors using patient-reported outcome measures (PROMs) is relatively recent. This scoping review aims to guide decision making in the development of PROMs programs for patients receiving immune checkpoint inhibitor therapy.
Methods: Four electronic databases were searched from inception to January 2024.
Article Synopsis
- Endolymphatic hydrops, an increase in fluid within the cochlea, is a key feature of Meniere's disease, which causes symptoms like vertigo, fluctuating hearing loss, and tinnitus.
- The study explored the relationship between endolymphatic hydrops and cochlear synaptopathy (a type of hearing loss) using imaging techniques on transgenic mice subjected to blast noise and osmotic changes.
- Findings indicated that while both conditions can occur after noise exposure, endolymphatic hydrops does not cause cochlear synaptopathy; instead, they are independent effects resulting from damage to hair cell structures.
Article Synopsis
- This study explores how circadian preference (morning vs. evening tendencies) and sleep inertia (feeling sluggish after waking) affect marathon performance, especially since marathons typically happen in the early morning.
- Researchers recruited 936 participants from a 2016 city marathon and found that runners with a preference for the evening and higher sleep inertia tended to have slower completion times.
- The findings suggest that understanding these factors could help tailor training programs for specific runners, potentially improving their performance during races.