Publications by authors named "M Granda"
After an enriching year in the editorial internship program at the American Journal of Kidney Diseases (AJKD), we reflect on the valuable lessons that we learned throughout the year. Engaging in the editorial and medical publishing process, we gained experience in critical appraisal and the role of scholarship in the nephrology community. In this Perspective, each editorial intern highlights five manuscripts published in AJKD between August 2023 and June 2024, offering commentary on specific aspects that, in our perspective, hold particularly high clinical or research significance.
View Article and Find Full Text PDFProximal Tubule Secretory Clearance, Injury, and Kidney Viability in Cirrhosis.
Clin Transl Gastroenterol
November 2024
Article Synopsis
- The study examines how cirrhosis affects kidney functionality, particularly focusing on tubular structures, which are crucial for managing metabolites and electrolytes, rather than just glomerular filtration rate (GFR).
- Researchers collected plasma and urine samples from cirrhotic patients and matched controls to evaluate tubular injury and viability markers, specifically KIM-1 (kidney injury molecule-1) and EGF (epidermal growth factor).
- Findings showed that patients with cirrhosis had significantly higher levels of KIM-1 and EGF, indicating tubular injury yet demonstrated preserved tubular secretory function, suggesting a mix of chronic injury while maintaining functionality in stable cirrhosis cases.
Article Synopsis
- * Water samples were tested for 46 contaminants, including pesticides and pharmaceuticals, with bioassays revealing that certain receptors showed activity levels indicative of potential toxicity at various sites.
- * The findings suggest that while chemical analysis and EAR can help prioritize known contaminants, bioassays are better at identifying both known and unknown harmful chemicals, making them more effective for assessing water quality and safety.
Importance: COVID-19 may injure the kidney tubules via activation of inflammatory host responses and/or direct viral infiltration. Most studies of kidney injury in COVID-19 lacked contemporaneous controls or measured kidney biomarkers at a single time point.
Objectives: To better understand mechanisms of acute kidney injury in COVID-19, we compared kidney outcomes and trajectories of tubular injury, viability, and function in prospectively enrolled critically ill adults with and without COVID-19.
Background: Coronavirus disease-2019 (COVID-19) may injure the kidney tubules via activation of inflammatory host responses and/or direct viral infiltration. Most studies of kidney injury in COVID-19 lacked contemporaneous controls or measured kidney biomarkers at a single time point. To better understand mechanisms of AKI in COVID-19, we compared kidney outcomes and trajectories of tubular injury, viability, and function in prospectively enrolled critically ill adults with and without COVID-19.
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