Publications by authors named "M Gorno-Tempini"
Script training is a speech-language intervention designed to promote fluent connected speech via repeated rehearsal of functional content. This type of treatment has proven beneficial for individuals with aphasia and apraxia of speech caused by stroke and, more recently, for individuals with primary progressive aphasia (PPA). In the largest study to-date evaluating the efficacy of script training in individuals with nonfluent/agrammatic primary progressive aphasia (nfvPPA; Henry et al.
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- Poor affect recognition is an early indicator of frontotemporal dementia (FTD), and this study used the Comprehensive Affect Testing System (CATS-A) to assess emotional dysfunction in FTD patients compared to healthy controls.
- The study involved 139 FTD patients of various subtypes and tested them alongside 116 healthy controls, measuring their Affective Recognition Quotient (ARQ) to evaluate emotional recognition accuracy.
- Results showed that the CATS-A effectively differentiated between FTD patients and healthy controls with high accuracy (AUC 0.89) and had robust internal reliability, suggesting it's a valuable clinical tool for assessing emotional dysfunction in FTD.
Based on historic observations that children with reading disabilities were disproportionately both male and non-right-handed, and that early life insults of the left hemisphere were more frequent in boys and non-right-handed children, it was proposed that early focal neuronal injury disrupts typical patterns of motor hand and language dominance and in the process produces developmental dyslexia. To date, these theories remain controversial. We revisited these earliest theories in a contemporary manner, investigating demographics associated with reading disability, and in a subgroup with and without reading disability, compared structural imaging as well as patterns of activity during tasks of verb generation and non-word repetition using magnetoencephalography source imaging.
View Article and Find Full Text PDFCross-linguistic studies with healthy individuals are vital, as they can reveal typologically common and different patterns while providing tailored benchmarks for patient studies. Nevertheless, cross-linguistic differences in narrative speech production, particularly among speakers of languages belonging to distinct language families, have been inadequately investigated. Using a picture description task, we analyze cross-linguistic variations in connected speech production across three linguistically diverse groups of cognitively normal participants-English, Chinese (Mandarin and Cantonese), and Italian speakers.
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- Semantic dementia (SD) patients, particularly those with semantic variant primary progressive aphasia (svPPA) and semantic behavioral variant frontotemporal dementia (sbvFTD), exhibit challenges in identifying faces due to atrophy in the anterior temporal lobe (ATL).
- The study involved 74 SD patients and 36 healthy controls, who underwent various face recognition and semantic processing tests, alongside structural MRI scans to assess neural correlates.
- Findings indicated that while both patient groups struggled with semantic face tasks, they performed similarly on perceptual face tests, suggesting that perceptual deficits may not arise until later stages of the disease with more extensive ATL atrophy.