Semilobar Holoprosencephaly Caused by a Novel and De Novo Pathogenic Variant.

Holoprosencephaly (HPE) is the most common embryonic forebrain developmental anomaly. It involves incomplete or absent division of the prosencephalon into two distinct cerebral hemispheres during the early stages of organogenesis. HPE is etiologically heterogeneous, and its clinical presentation is very variable.

1 kW, 200 mJ picosecond thin-disk laser system.

We report on a laser system based on thin-disk technology and chirped pulse amplification, providing output pulse energies of 200 mJ at a 5 kHz repetition rate. The amplifier contains a ring-type cavity and two thin Yb:YAG disks, each pumped by diode laser systems providing up to 3.5 kW power at a 969 nm wavelength.

42 W femtosecond Yb:LuO regenerative amplifier.

We report on a femtosecond high-power regenerative amplifier based on Yb:LuO. Exploiting the excellent thermo-mechanical properties of this material, we were able to achieve up to 64.5 W in continuous-wave regime, limited only by the available pump power.

Pulse compression to subcycle field waveforms with split-dispersion cascaded hollow fibers.

Carefully dispersion- and nonlinearity-managed cascades of gas-filled hollow-core fibers enable, as our theoretical analysis shows, efficient pulse compression with ultrahigh compression ratios. With dispersion and nonlinearity of individual fibers in such cascades optimized toward distinctly different goal functions, millijoule picosecond laser pulses can be compressed to sub-100-GW subcycle field waveforms.

High-power pulsed diode-pumped Er:ZBLAN fiber laser.

We report on the operation and performance of a gain-switched Er:ZBLAN fiber laser based on an active pulsed diode pump system. The produced laser pulses offer high peak powers while retaining the high average powers and efficiency of the cw regime. The measured pulse duration was about 300 ns and nearly independent of the pump repetition frequency.