Publications by authors named "M Goren"
The evolutionary arms race between bacteria and phages led to the emergence of bacterial immune systems whose diversity and dynamics remain poorly understood. Here we use comparative genomics to describe a widespread genetic element, defined by the presence of the Gamma-Mobile-Trio (GMT) proteins, that serves as a reservoir of offensive and defensive tools. We demonstrate, using Vibrio parahaemolyticus as a model, that GMT-containing genomic islands are active mobile elements.
View Article and Find Full Text PDFObjective: Information regarding pregabalin use is limited. We aimed to assess the outcome of the patients who have taken pregabalin at a certain time during their pregnancies.
Methods: 31 patients used pregabalin treatment during pregnancy and 93 control patients were included in the study who applied to hospital between the years 2013-2022.
Purpose: The purpose of this study was to evaluate the effect of carbohydrate loading prior to the cesarean surgery under spinal anesthesia on thiols and ischemia-modified albumin (IMA) levels.
Design: Prospective, randomized placebo-controlled study.
Methods: Seventy-nine pregnant women planned for cesarean sections under spinal anesthesia at Karaman Training and Research Hospital were randomized into a control group (group C) (n = 42), and an oral carbohydrate preloading group (group OCH) (n = 37).
Obtaining sperm from the testis surgically and using these sperm with the intracytoplasmic sperm injection technique, has opened the way for the possibility of biological fathering in men with non-obstructive azoospermia (NOA). We aimed to evaluate our sperm retrieval rate (SRR) by microdissection testicular sperm extraction (micro-TESE) in NOA patients with solitary testis. In this retrospective case-control study, fortyfive patients with NOA who had a congenital or acquired solitary testis were included, between September 2003 and January 2022.
View Article and Find Full Text PDFArticle Synopsis
- - Scientists are exploring the use of CRISPR-Cas systems as targeted antimicrobials against bacterial infections, particularly focusing on multidrug-resistant strains of Klebsiella pneumoniae.
- - The study found that DNA-targeting Cas nucleases were more effective than RNA-targeting ones, with AsCas12a showing promising results, although different guide RNAs had varying effectiveness based on strain-specific factors.
- - A genome-wide screen identified design rules for guide RNAs and helped develop an algorithm to predict their efficiency, ultimately demonstrating that Cas12a can be used in phagemids to eliminate K. pneumoniae.