Publications by authors named "M Goodier"
Article Synopsis
- Oral rotavirus vaccines show reduced effectiveness in low-income areas where early childhood human cytomegalovirus (HCMV) infections are common, potentially affecting immune responses.
- A study measured antibodies in vaccinated infants, finding no overall link between HCMV infection status and rotavirus antibody levels; however, HIV-exposed-uninfected infants with HCMV showed significantly lower antibody responses.
- The findings suggest that while HCMV may not broadly impact rotavirus vaccine responses in all infants, its effects on vulnerable groups like HIV-exposed infants warrant further investigation for improving vaccine effectiveness.
Oral rotavirus vaccines show diminished immunogenicity in low-resource settings where rotavirus burden is highest. This study assessed the safety and immune boosting effect of a third dose of oral ROTARIX (GlaxoSmithKline) vaccine administered at 9 months of age. A total of 214 infants aged 6 to 12 weeks were randomised to receive two doses of ROTARIX as per standard schedule with other routine vaccinations or an additional third dose of ROTARIX administered at 9 months old concomitantly with measles/rubella vaccination.
View Article and Find Full Text PDFNatural killer cells play an important role in the control of viral infections both by regulating acquired immune responses and as potent innate or antibody-mediated cytotoxic effector cells. NK cells have been implicated in control of Ebola virus infections and our previous studies in European trial participants have demonstrated durable activation, proliferation and antibody-dependent NK cell activation after heterologous two-dose Ebola vaccination with adenovirus type 26.ZEBOV followed by modified vaccinia Ankara-BN-Filo.
View Article and Find Full Text PDFCellular immunity against rotavirus in children is incompletely understood. This review describes the current understanding of T-cell immunity to rotavirus in children. A systematic literature search was conducted in Embase, MEDLINE, Web of Science, and Global Health databases using a combination of "t-cell", "rotavirus" and "child" keywords to extract data from relevant articles published from January 1973 to March 2020.
View Article and Find Full Text PDFInter-rater reliability in quality assurance (QA) of pediatric chest X-rays.
J Med Imaging Radiat Sci
September 2021
Purpose: The goal of the study is to determine the inter-rater agreement on multiple factors that were utilized to evaluate the quality of pediatric chest X-ray exams from different levels of healthcare provision in an African setting.
Methods: The image quality of pediatric chest X-rays from 3 South African medical centers of varying level of healthcare service were retrospectively assessed by 3 raters for 12 quality factors including: (1) absent body parts; (2) under inspiration; (3) patient rotation; (4) scapula in the way; (5) patient kyphosis/lordosis; (6) artefact/foreign body; (7) central vessel visualization; (8) peripheral vessels visualization; (9) poor collimation; and (10) trachea and bronchi visualization; (11) post-cardiac vessel visualization; and (12) absent or wrong image orientation. Analysis was performed using the Brennan--Prediger coefficient of agreement for inter-rater reliability and Cochran's Q statistic and McNemar's test for inter-rater bias.