Publications by authors named "M Gonzalez-Hernandez"
The effectiveness of SARS-CoV-2 therapeutic antibodies targeting the spike (S) receptor-binding domain (RBD) has been hampered by the emergence of variants of concern (VOCs), which have acquired mutations to escape neutralizing antibodies (nAbs). These mutations are not evenly distributed on the RBD surface but cluster on several distinct surfaces, suggesting an influence of the targeted epitope on the capacity to neutralize a broad range of VOCs. Here, we identified a potent nAb from convalescent patients targeting the receptor-binding domain of a broad range of SARS-CoV-2 VOCs.
View Article and Find Full Text PDFIntroduction: The occiput-posterior (OP) fetal position is the most frequent form of labor dystocia. This position has been associated with delaying the second stage of labor and adverse outcomes.
Objectives: This project aimed to improve the quality of intrapartum care provided by midwives for OP fetal positions during the second stage of labor.
Article Synopsis
- - The rise of MASLD and MASH-related fibrosis is growing globally, yet current drug therapies face challenges due to diverse patient responses and inadequate preclinical models.
- - Researchers used a large dataset to explore the reasons behind patient differences, applying methods like weighted gene co-expression network analysis (WGCNA) to identify six distinct patient subgroups based on gene expression patterns.
- - Their findings suggest that recognizing these subgroups could enhance patient stratification and lead to targeted treatments, highlighting the need for further research to understand these groups better and find specific protein targets for future therapies.
Electrical stimulation has emerged as a cornerstone technique in the rapidly evolving field of biomedical engineering, particularly within the realms of tissue engineering and regenerative medicine. It facilitates cell growth, proliferation, and differentiation, thereby advancing the development of accurate tissue models and enhancing drug-testing methodologies. Conductive hydrogels, which enable the conduction of microcurrents in 3D cultures, are central to this advancement.
View Article and Find Full Text PDFPRESENCE OF ANTI-NEOSPORA CANINUM ANTIBODIES IN TEMAZATE DEER (MAZAMA TEMAMA) AND WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) FROM THE CENTRAL REGION OF VERACRUZ, MEXICO.
J Parasitol
May 2024
Article Synopsis
- * Overall, 57.7% of the deer tested positive for these antibodies, with similar rates in both deer species; higher prevalence was observed in female deer and adults compared to younger ones.
- * The research indicated that adult age was a significant risk factor for antibody presence, suggesting environmental contamination with oocysts and the role of deer in the sylvatic cycle of N. caninum.