Complexation Hydrogels for the Oral Delivery of Growth Hormone and Salmon Calcitonin.

The hydrogel system of poly(methacrylic acid-co-N-vinyl pyrrolidone) was evaluated for use as an oral delivery system for growth hormone and salmon calcitonin. These proteins were selected because of their therapeutic importance and the insight provided by evaluating the delivery of a therapeutic agent with a high molecular weight (growth hormone) and a drug with a high isoelectric point (salmon calcitonin). Growth hormone loading and release studies were performed for both P(MAA-co-NVP) and P(MAA-g-PEG).

Characterization and superficial transformations on mini-matrices made of interpolymer complexes of chitosan and carboxymethylcellulose during in vitro clarithromycin release.

Different interpolymer complexes (IPCs) of chitosan (CS) and carboxymethylcellulose sodium salt (CMC) were used to elaborate mini-matrices containing clarithromycin (CAM). IPCs were characterized by FTIR, DSC and powder X-ray (XRD). Compression processes did not modify the physical state of CAM which was in its polymorph Form II.

Chitosan-carboxymethylcellulose interpolymer complexes for gastric-specific delivery of clarithromycin.

Chitosan (CS) and carboxymethylcellulose (CMC) sodium interpolymer complexes were formed using the novel method "tablets-in-capsule" for stomach drug delivery. The aim of this study was to investigate the influence of the molecular weight (M.wt.