Publications by authors named "M Gomez de Terreros Guardiola"
Background: Apolipoprotein (apo) C-III is involved in several processes that increase triglyceride levels, inflammation, and insulin resistance. Four of its proteoforms have been the focus of several studies and have shown differential associations with cardiovascular risk biomarkers, mostly lipids. However, there are other proteoforms of apoC-III that have not yet been investigated in detail.
View Article and Find Full Text PDFGrowth differentiation factor 15 (GDF15) is a stress-response cytokine related to a wide variety of metabolic diseases. However, the impact of GDF15-specific genetic variants on the abovementioned conditions is poorly known. The aim of this study was to assess the impact of selected GDF15 single-nucleotide polymorphisms (SNPs) on metabolic disturbances and subclinical atherosclerosis.
View Article and Find Full Text PDFBackground: Obesity is a complex, diverse and multifactorial disease that has become a major public health concern in the last decades. The current classification systems relies on anthropometric measurements, such as BMI, that are unable to capture the physiopathological diversity of this disease. The aim of this study was to redefine the classification of obesity based on the different H-NMR metabolomics profiles found in individuals with obesity to better assess the risk of future development of cardiometabolic disease.
View Article and Find Full Text PDFSurvival and Risk Factors Associated with Mortality in Patients with Sleep Apnoea in Colombia: A Retrospective Cohort Study.
Nat Sci Sleep
October 2024
Article Synopsis
- A retrospective cohort study assessed five-year survival rates of patients with sleep apnea (SA) in Colombia from 2005 to 2022, focusing on variables like age, sex, and comorbidities.
- The overall five-year survival rate was 94.6%, with significant decreases for individuals over 65 (88.5%) and those with cardiovascular disease (89%).
- Key risk factors linked to decreased survival included older age, male sex, cardiovascular diseases, chronic obstructive pulmonary disease (COPD), chronic kidney disease (CKD), and metastatic cancer.
Article Synopsis
- Cardiovascular disease is a major concern for individuals with diabetes, even with normal LDL cholesterol levels, due to dyslipidaemia that includes high triglycerides and low HDL cholesterol.
- Understanding the complex relationship between lipoprotein composition and cardiovascular risk is crucial for recognizing hidden threats in diabetes patients.
- The review emphasizes three levels of lipoprotein analysis—routine tests, advanced NMR profiling, and the study of minor lipoprotein components—to improve research on cardiovascular disease in diabetes populations.