Reflection of tolerance to alcohol in the structure of the sleep wakefulness cycle.

The purpose of the present work was to study the effects of tolerance to ethanol on the sleep-wakefulness cycle (SWC) structure. Experiments were carried out in chronic conditions on the adult cats (n=5). The following methods were used: the stereotaxic - for implanting electrodes; polysomnographic - for EEG registration of the SWC structure.

Opioid system of the brain and ethanol.

Influence of blocking of opioid receptors with concomitant intraperitoneal injections of Naloxone (20 mg/kg) (non-selective antagonist of opioid system) on the outcomes of anesthetic dose of ethanol (4,25 ml /kg 25% solution) was investigated in the rats. The sleep-wakefulness cycle (SWC) was used as a model for identification of the effects. Alterations of the SWC structure adequately reflect the neuro-chemical changes, which may develop during pharmacological and non-pharmacological impact.

[Effect of various doses of ethanol on the structure of the wakefulness-sleep cycle in cats].

I.p. administration of 25% ethanol solution with a gradual increase of the dose from 1 to 2 g/kg prolonged the wakefulness, reduced the slow-wave sleep, inhibited the paradoxical phase, and caused a fragmentation of the sleep-wakefulness cycle.