Assessing the biocompatibility of a dental composite product.

Objective: The purpose of the study was to assess the biocompatibility of a composite material considering the reaction caused at the implant site during 21 days by daily observing the subjects' behavior as well as by macroscopic examination and histological examination upon expiry of the testing period.

Materials And Methods: We performed the tolerance test by implant of the composite material Dualcim. The implant test was made on two species of lab animals, Guinea pigs and Wistar rats in two versions: subcutaneous implant and intramuscular÷perimuscular implant.

Biology and cytotoxicity of dental materials: an in vitro study.

Objective: The purpose of the experiment was to determine the degree of biocompatibility of a sealer (RO, laboratory made product) dental material in terms of cytotoxicity and animal tests.

Materials And Methods: In the present study, the biological compatibility of eight experimental composite materials was examined by in vitro methods. The bio-composites used for the cytotoxicity test were placed into direct contact with normal human fibroblasts in a cell-culture dish.