Publications by authors named "M Glenet"
Major 5'-terminally deleted (5'TD) RNA forms of group-B coxsackievirus (CVB-5'TD) has been associated with myocarditis in both mice and humans. Although it is known that interferon-β (IFN-β) signaling is critical for an efficient innate immune response against CVB-induced myocarditis, the link between CVB-5'TD RNA forms and type I IFN signaling in cardiomyocytes remains to be explored. In a mouse model of CVB3/28-induced myocarditis, major early-emerging forms of CVB-5'TD RNA have been characterized as replicative viral populations that impair IFN-β production in the heart.
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- A study analyzed 150 nasopharyngeal samples from outpatient cases in northeastern France during the emergence of the SARS-CoV-2 Omicron variant in December 2021, finding that only 3 samples (2%) were Omicron variants while 147 (98%) were delta variants.
- Phylogenetic analysis suggested that the early Omicron strains might have originated from South Africa or India, and an uncharacterized spike mutation (Y170W) was identified, which was weakly present during this period.
- The study concluded that a routine whole-genome sequencing approach is crucial for understanding and tracking the genotypic changes of SARS-CoV-2 variants, which could inform public health policies.
Article Synopsis
- The COVID-19 pandemic has significantly impacted the follow-up care of people living with HIV in N'djamena, Chad, particularly increasing the rates of loss to follow-up (LTFU) from 2019 to 2022.
- The highest incidence of LTFU occurred in the first quarter of 2020, prior to the reported cases of SARS-CoV-2 in the region, indicating early disruptions in care.
- Despite these challenges, the overall mortality among this population remained low and was not directly influenced by COVID-19 infection waves, highlighting the importance of maintaining HIV care during health crises.
We assessed relationships between early peripheral blood type I interferons (IFN) levels, clinical new early warning scores (NEWS), and clinical outcomes in hospitalized coronavirus disease-19 (COVID-19) adult patients. Early IFN-β levels were lower among patients who further required intensive care unit (ICU) admission than those measured in patients who did not require an ICU admission during severe acute respiratory syndrome coronavirus type 2 infection. IFN-β levels were inversely correlated with NEWS only in the subgroup of patients who further required ICU admission.
View Article and Find Full Text PDFBackground: Understanding patterns of environmental contamination by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for infection prevention policies.
Methods: We screened surfaces and air samples from single-bed intensive-care unit rooms of adult patients with coronavirus disease 2019 (COVID-19) for SARS-CoV-2 RNA and viable viruses.
Results: We evidenced viral RNA environmental contamination in 76% of 100 surfaces samples and in 30% of 40 air samples without any viable virus detection by cell culture assays.