Morphometric studies on melanocytic tumors.

The authors have studied the longest and the shortest nuclear axes, the ratio between nuclear axes, the nuclear areas and the mitotic indices in melanocytic tumors and have noted progressive changes of the values in superficial spreading and in nodular melanoma as compared to nevi. The most powerful discriminants were the mitotic index and the ratio between the nuclear axes. These findings are discussed in relationship with the tumor progression.

[Minute chromosomes in a case of chronic Ph1-positive myeloid leukemia].

Minute chromosomes (mins) were found in all bone marrow cells in a 62-year-old woman with Ph1 positive chronic myeloid leukemia. The cells had a range of 39 to 50 chromosomes with a mode of 46. The examined metaphases had a variety of numerical and structural chromosome abnormalities, as well as 2 to 6 minute chromosomes.

[Chromosome changes on 20 lesions of cervix uteri ].

Cytogenetic studies on biopsies of cervix uteri (5 dysplasias, 2 carcinomas in situ and 13 invasive carcinomas) are reported in this paper in order to detect the numerical and structural chromosome changes. In dysplasias, the deviation number is mostly restricted around the diploid mode while in carcinomas the range of deviation is wider and more than one modal number could be identified. Structural aberrations of chromosome 1 were found in one case of dysplasia and in 10 cases of invasive carcinomas.

Incidence and significance of micronuclei in pernicious anemia.

The incidence of micronuclei in bone marrow erythroblasts of patients with pernicious anemia ranged between 0.5-5.6% as compared with the value of 0-0.