Publications by authors named "M Giovannoni"
The enzymatic hydrolysis of cell wall polysaccharides results in the production of oligosaccharides with nature of damage-associated molecular patterns (DAMPs) that are perceived by plants as danger signals. The in vitro oxidation of oligogalacturonides and cellodextrins by plant FAD-dependent oligosaccharide-oxidases (OSOXs) suppresses their elicitor activity in vivo, suggesting a protective role of OSOXs against a prolonged activation of defense responses potentially deleterious for plant health. However, OSOXs are also produced by phytopathogens and saprotrophs, complicating the understanding of their role in plant-microbe interactions.
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- - This study focuses on developing new pyrazolo[1,5-a]quinazoline compounds that modify GABA receptors by incorporating oxygen or nitrogen at the 8-position.
- - The compounds were tested on defined GABA receptor types using an electrophysiological approach, identifying several promising candidates for further research based on their effects on chlorine currents.
- - Additionally, molecular modeling and statistical analysis (HCA) were used to classify the compounds according to their pharmacological effects, identifying key receptor residues that influence whether a compound acts as an agonist or antagonist.
Article Synopsis
- Recent research has focused on anti-doping interventions, but there is limited evidence on their effectiveness across different populations, prompting the study of a psychological intervention by Kavussanu et al. (2022) in young Italian athletes.* -
- The study involved 121 athletes from 15 sport clubs in Italy who received either a psychological intervention, an educational intervention, or were placed in a no-intervention control group, with measures taken before, after, and two months later.* -
- Results showed that both interventions effectively reduced doping likelihood and increased anticipated guilt compared to the control group, with these positive effects maintained over time, emphasizing the importance of addressing psychological factors in anti-doping education.*
Article Synopsis
- In plants, cell wall fragments like oligogalacturonides (OGs) trigger immune responses by activating signal transduction pathways.
- Research on the protein DET3, a subunit of the vacuolar H-ATPase, revealed that its knockdown mutant (det3) showed reduced activation of defensive genes and other immune responses when exposed to OGs.
- The det3 mutant also demonstrated impaired endocytosis of OGs, linking DET3 to the internalization of these molecules, which is vital for maintaining a strong defense against pathogens like Botrytis cinerea.
Chronic inflammation contributes to a number of diseases. Therefore, control of the inflammatory response is an important therapeutic goal. To identify novel anti-inflammatory compounds, we synthesized and screened a library of 80 pyrazolo[1,5-]quinazoline compounds and related derivatives.
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