Publications by authors named "M Giovanna Pallotti"
Article Synopsis
- Primary squamous cell carcinoma (SCC) can arise in various body parts, with primary gastric squamous cell carcinoma (GSCC) being particularly rare, exemplified by a case of a 72-year-old woman diagnosed with it.
- Diagnostic imaging, including CT scans and ultrasound-endoscopy, revealed a significant mass at the celiac tripod, leading to further tests confirming poorly differentiated carcinoma with squamous differentiation.
- The study emphasizes the need for well-defined diagnostic criteria for GSCC due to the lack of consensus in current classifications, suggesting that a standardized diagnostic panel might improve accuracy.
Background: Opioids in step III of the WHO analgesic ladder are the standard of care for treating cancer pain. However, a significant minority of patients do not benefit from therapy. Genetics might play a role in predisposing patients to a good or poor response to opioids.
View Article and Find Full Text PDFArticle Synopsis
- Opioids are commonly used to manage cancer pain, but 10%-20% of patients either do not respond well or suffer from negative side effects, potentially due to genetic differences.
- A genome-wide association study (GWAS) was conducted on cancer patients across Europe to find genetic markers related to opioid-induced nausea and vomiting.
- The study identified 65 genetic variants linked to nausea-vomiting scores, including variants in the NPAS2 gene, paving the way for more personalized cancer pain management strategies through further research.