The philosophical coming of age of science. Euler's role in Cassirer's early philosophy of space and time.

Cassirer's early philosophy of space and time, overshadowed by his later work on relativity, has been scarcely explored in the literature. This paper aims to bridge this gap. It argues that understanding Cassirer's point of view requires acknowledging the pivotal role he attributed to the work of Leonhard Euler in the philosophical 'coming of age' of modern science.

Variability and substantiality. Kurd Lasswitz, the Marburg school and the neo-Kantian historiography of science.

A trained physicist, Kurd Lasswitz (1848-1910) is best known as a novelist, the father of modern German science fiction, and as a historian of science, the initiator of the modern historiography of atomism. In the late 19th century, Lasswitz engaged in an intense dialogue with the emerging Marburg school of neo-Kantianism, contributing to shaping most of its defining tenets. By the end of the decade, this research had grown into a two-volume Geschichte der Atomistik (1890), which remains the most successful example of neo-Kantian historiography of science.

Toxicological Assessments of a Pandemic COVID-19 Vaccine-Demonstrating the Suitability of a Platform Approach for mRNA Vaccines.

The emergence of SARS-CoV-2 at the end of 2019 required the swift development of a vaccine to address the pandemic. Nonclinical GLP-compliant studies in Wistar Han rats were initiated to assess the local tolerance, systemic toxicity, and immune response to four mRNA vaccine candidates encoding immunogens derived from the spike (S) glycoprotein of SARS-CoV-2, encapsulated in lipid nanoparticles (LNPs). Vaccine candidates were administered intramuscularly once weekly for three doses at 30 and/or 100 µg followed by a 3-week recovery period.

Motivational Kantianism: Cassirer's late shift towards a regulative conception of the apriori.

Cassirer often pointed out that the physics of his time had progressively become a 'physics of principles' rather than a 'physics of models'. Until the 1920s, Cassirer regarded these principles (the energy principle, the relativity principle etc.) as a constitutive but provisional form of the a priori, imposing specific limitations on the form of the allowable laws of nature.