Publications by authors named "M Ginny"
Resistance of Plasmodium falciparum (Pf) and P. vivax (Pv) to standard antimalarials is widespread in Papua New Guinea (PNG). The objective of the study was to assess the rate of clinical treatment failure (TF) and parasite resistance to amodiaquine (AQ), chloroquine (CQ) and quinine+sulfadoxine/pyrimethamine (Q+SP) for malaria in a rural health centre of the East Sepik Province.
View Article and Find Full Text PDFArticle Synopsis
- A trial in Papua New Guinea evaluated the safety and efficacy of Cotrifazid, a combination of cotrimoxazole, rifampicin, and isoniazid, against drug-resistant malaria compared to mefloquine and standard treatment with quinine and sulfadoxine-pyrimethamine.
- Patients of all ages with recurrent uncomplicated malaria participated, and results showed Cotrifazid had fewer adverse events but a higher rate of parasitological failure compared to mefloquine and quinine + SP.
- Although Cotrifazid showed short-term clinical effectiveness similar to the other treatments, the significant parasitological failures indicate it may not be suitable in its current form for long-term use against
Using in vivo samples from treatment failure malaria cases, we demonstrate the high sensitivity of the parasite lactase dehydrogenase (pLDH)-based OptiMAL rapid diagnostic test in the detection of P. falciparum gametocytes. This high sensitivity limits the use of pLDH-based tests in the monitoring of treatment outcomes in circumstances where gametocytemia is common.
View Article and Find Full Text PDFA study was conducted in Papua New Guinea to analyze Plasmodium falciparum drug resistance polymorphisms in patients presenting with resistant malaria. One hundred ninety-nine P. falciparum-positive patients were recruited at two sites, Madang and Maprik.
View Article and Find Full Text PDF