Publications by authors named "M Gimeno"
Background: Alternative Splicing (AS) is a post-transcriptional process that allows a single RNA to produce different mRNA variants and, in some cases, multiple proteins. Various processes, many yet to be discovered, regulate AS. This study focuses on regulation by RNA-binding proteins (RBPs), which are not only crucial for splicing regulation but also linked to cancer prognosis and are emerging as therapeutic targets for cancer treatment.
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- - Osteoarthritis (OA) is a major disability issue exacerbated by aging populations and obesity, leading to a surge in healthcare challenges, with a variety of treatment options available.
- - A study explored the long-term benefits of a single hyaluronic acid (HA) injection for knee OA in patients from the SOYA trial, revealing that 81.5% experienced sustained improvements over six months, linked to better daily functioning and high satisfaction.
- - The findings indicated that younger age and milder OA were associated with longer-lasting effects, supporting the use of Adant Plus as a safe and effective treatment for mild to moderate knee OA, with clinical follow-up playing a vital role in understanding its practical application.
Article Synopsis
- - The study compared the accuracy and precision of two devices, Argos and Eyestar 900, for measuring axial length in cataract surgery patients in Barcelona, analyzing factors like agreement and repeatability.
- - A total of 107 patients (average age 73) were evaluated, showing a negligible median difference in measurements (only -0.01 mm) and very high agreement (96.1% of eyes within ±0.50 D).
- - Despite small differences in measurements, Argos and Eyestar 900 are not interchangeable for very long or short eyes due to their distinct methodologies for calculating axial length.
Silver bis(carbene) complexes featuring ditopic N-heterocyclic carbene (NHC) ligands have been synthesized which enable the assembly of supramolecular architectures via reaction with silver triflate. Through a systematic exploration of crystal structures and emissive properties, this study investigates the impact of the substituents on the NHC ditopic ligands [R-Im-2-Z-py], where R = Me, benzyl (Bz), or 2-naphthylmethyl (NaphCH), and Z = H or Cl in the structural framework and emissive properties observed in the silver bis(carbene) or polynuclear species. Remarkably diverse structural motifs emerge in both of them, predominantly influenced by the choice of R wingtip and second by the Z substituent.
View Article and Find Full Text PDFLissencephaly and cerebellar hypoplasia (LCH) represents a spectrum of congenital developmental malformations of the cerebral cortex and cerebellum, mostly occurring as inherited conditions caused by variants in an increasingly recognized number of genes. LCH has been identified in three Dorset-cross lambs with congenital neurological signs in Australia. Lambs were unable to walk and had reduced vision, and one lamb developed a hypermetric gait and intention tremors.
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