Publications by authors named "M Gilman"
The peptidoglycan (PG) cell wall is critical for bacterial growth and survival and is a primary antibiotic target. MreD is an essential accessory factor of the Rod complex, which carries out PG synthesis during elongation, yet little is known about how MreD facilitates this process. Here, we present the cryo-electron microscopy structure of MreD in complex with another essential Rod complex component, MreC.
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- G-protein-coupled receptors (GPCRs) play a crucial role in regulating human physiology and are common targets for drugs, but selective binding of drugs to GPCRs is often limited.
- Researchers developed specialized heavy-chain-only antibodies, known as 'nanobodies', that can selectively act as antagonists for the angiotensin II type I receptor, revealing unique mechanisms of how they block receptor activity.
- The study demonstrates that these nanobodies can co-bind with small-molecule antagonists, providing a way to finely tune ligand selectivity, and highlights the potential of antibody fragments as advanced modulators for GPCRs in drug development.
Examination protocoling is a noninterpretive task that increases radiologists' workload and can cause workflow inefficiencies. The purpose of this study was to evaluate effects of an automated CT protocoling system on examination process times and protocol error rates. This retrospective study included 317,597 CT examinations (mean age, 61.
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