Autoimmune brainstem encephalitis: Clinical associations, outcomes, and proposed diagnostic criteria.

Objective: We describe neurologic phenotype, clinical associations, and outcomes in autoimmune brainstem encephalitis.

Methods: Medical records of neural-IgG positive autoimmune brainstem encephalitis patients diagnosed at Mayo Clinic (January 1, 2006-December 31, 2022) were reviewed.

Results: Ninety-eight patients (57 male) were included.

A complex and severe encephalitis associated with four co-existing neuronal cell-surface autoantibodies.

Many forms of autoimmune encephalitis are mediated by neuronal cell-surface directed autoantibodies. The co-occurrence of four neuronal cell-surface antibodies in a single patient is exceptionally rare. We report a patient who had a severe encephalitis associated with antibodies to NMDA, Glycine, GABA and GABA receptors.

Digital Contact as Strain or Support: How Does Type of Contact Shape the Association Between Mother-Child Interactions and Adult Children's Depressive Symptoms in Later-Life Families?

Background And Objectives: This paper aims to extend research on the association between mother-child contact and adult children's psychological well-being in later-life families by differentiating between in-person, virtual, and written digital contact, examining the moderating role of children's gender, and exploring the processes that underlie these associations.

Research Design And Methods: Mixed-methods data were collected from 250 adult children nested within 131 families as part of the third wave of the Within-Family Differences Study. On average, adult children were 59 and mothers were 88 years of age.

How Gender Shapes Sibling Tension in Adulthood Following Parental Death.

Objective: This study investigates gender differences in the effect of parents' deaths on sibling tension among bereaved adult children.

Background: Previous scholarship on adult sibling relations following the deaths of parents presents inconsistent results. These disparate findings may stem from past studies not taking into consideration the gender of both the deceased parent and the bereaved child.

Worrying Across the Generations: The Impact of Adult Grandchildren's Problems on Grandparents' Well-Being.

Objectives: The intergenerational stake hypothesis and theories of the life course posit that older generations are invested in the well-being of younger generations. Consistent with this, previous research has shown that adult children's problems are associated with worse parental well-being. Because multigenerational ties have become increasingly important in the 21st century, we propose that adult grandchildren's problems may also impact grandparents' well-being.