Comparison of Injuries in the First 3 Years of Premier Rugby Sevens Between Male and Female Players.

Background: Premier Rugby Sevens (PR7S) is a new professional rugby league. Our study aims to examine injury data from PR7S over the last 3 years to clarify the incidence of injury per event and determine any trends within injuries to specific body regions related to both sex and year of competition. Understanding these injury patterns will assure relevant player education campaigns related to injury awareness, inform sex-specific injury prevention strategies, and help medical professionals care for athletes more effectively in future competitions.

Programmable mRNA therapeutics for controlled epigenomic modulation of single and multiplexed gene expression in diverse diseases.

Pathogenic gene dysregulation can be attributed to chromatin state change that pre-transcriptionally regulates expression. Recent breakthroughs elucidating the rules governing this DNA control layer, an epigenetic code, unlock a modality in precision medicine to target gene dysregulation across myriad diseases. Here we present a modular platform to design programmable mRNA therapeutics, Epigenomic Controllers (EC), that control gene expression through directed epigenetic change.

Incorporating Circulating Tumor DNA Testing Into Clinical Trials: A Position Paper by the National Cancer Institute GI Oncology Circulating Tumor DNA Working Group.

Purpose: Circulating tumor DNA (ctDNA) is an emerging tool in the evaluation of GI cancers. Challenges remain in defining its utility and role as a primary end point in therapeutic trials. The National Cancer Institute (NCI) ctDNA GI working group was created to evaluate current data and provide guidance on the inclusion of ctDNA in GI cancer trials.

Implementing a Tribally-Engaged Lung Cancer Screening Pilot Program in Rural Oklahoma.

The Tribally-Engaged Approaches to Lung Cancer Screening (TEALS) study aimed to co-design and test a community-based lung cancer screening (LCS) program within a large, tribally operated health system. In 2020-2021, we conducted a pre-post quasi-experimental pilot implementation study of a tailored and comprehensive LCS program in two Choctaw Nation of Oklahoma (CNO) primary care clinics in rural Oklahoma. The program included screening quality assessment, academic detailing, practice facilitation, health system enhancements, technology support, centralized LCS coordination, and community outreach.

Evaluating the implementation of inclisiran in primary care: process evaluation interim findings from interviews with key stakeholders.

Objectives: VICTORION-Spirit was a hybrid study designed to assess the feasibility of implementing inclisiran, a novel cholesterol-lowering treatment and behavioural support within primary care centres in England. This process evaluation aimed to evaluate the implementation of inclisiran for patients with elevated low-density lipoprotein cholesterol and atherosclerotic cardiovascular disease (ASCVD) or ASCVD-risk equivalents (n=900), from the perspectives of key stakeholders.

Design: VICTORION-Spirit was a phase IIIb, multicentre, randomised, controlled study.