Publications by authors named "M Giannoudi"
Objectives: To compare the manual dexterity and composure under pressure of people in different hospital staff roles using a buzz wire game.
Design: Prospective, observational, comparative study (Tremor study).
Setting: Leeds Teaching Hospitals NHS Trust, Leeds, UK, during a three week period in 2024.
Background: GDM and preeclampsia are common complications of pregnancy, for which overweight/obesity is a common risk factor. Both conditions are associated with a two-to-four-fold increase in future incident heart failure, which may be linked to early maladaptive myocardial changes.
Objectives: To determine maternal myocardial structural, functional, and energetic responses to pregnancies complicated by gestational diabetes mellitus (GDM) or preeclampsia compared to healthy pregnancies (HP) at third-trimester of pregnancy and twelve-months postpartum.
Less than full-time training, barriers and future needs. A UK-wide online survey of doctors in training.
J R Coll Physicians Edinb
September 2024
Background: The the current views of less-than full-time (LTFT) training by both LTFT and full-time (FT) doctors in training, with regards to health and well-being, clinical and non-clinical opportunities, in addition to associated future workforce implications and challenges, are uncertain.
Methods: We performed a cross-sectional study of UK-based doctors in training via an online questionnaire, designed and piloted by the Royal College of Physicians Edinburgh (RCPE) Trainees and Members Committee. Design was informed by prior investigation into LTFT training undertaken amongst similar populations by RCPE in 2019.
Aims: Diabetes mellitus (DM) increases heart failure incidence and worsens prognosis, but its molecular basis is poorly defined in humans. We aimed to define the diabetic myocardial transcriptome and validate hits in their circulating protein form to define disease mechanisms and biomarkers.
Methods And Results: RNA-sequencing data from the Genotype-Tissue Expression (GTEx) project was used to define differentially expressed genes (DEGs) in right atrial (RA) and left ventricular (LV) myocardium from people with vs.
Article Synopsis
- Type 2 diabetes (T2D) involves insulin resistance and abnormal insulin secretion, and this study compares the effects of two treatments: liraglutide (which boosts insulin secretion) and pioglitazone (which reduces insulin resistance) on heart health.
- The study involved 41 T2D patients and used various methods, including advanced imaging, to assess heart performance and function over two treatment periods with an 8-week washout in between.
- Results showed that pioglitazone significantly improved left ventricular (LV) mass and function, while liraglutide enhanced myocardial blood flow and perfusion reserve, indicating different benefits of each treatment approach for heart health in T2D patients.