Publications by authors named "M Ghosn"
High-flow pancreaticoduodenal artery (PDA) aneurysms secondary to celiac trunk occlusion or stenosis have a high risk of rupture. Embolization offers a less invasive alternative to surgery. We evaluated the effectiveness and safety of retrograde embolization via the superior mesenteric artery of high-flow PDA aneurysms without celiac trunk revascularization.
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- Stem cells exist in a dormant state within various tissues and can differentiate into new cells when needed, with mesenchymal stem cells being notable for their potential in tissue regeneration and immunomodulation.
- They release substances like paracrine factors and exosomes, which have various benefits such as reducing inflammation and promoting healing, indicating their importance in cell therapy and regenerative medicine.
- Aging hampers stem cells' ability to self-renew and differentiate, limiting regeneration, but advancements in therapy guidelines and clinical trials suggest that stem cell transplantation could be vital for combating age-related tissue damage.
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- Advances in immuno-oncology have improved treatment for renal cell carcinoma, but patients with "primary refractory" disease have poor outcomes; our study found a 19% prevalence of this group among 1,709 metastatic clear cell patients across 72 centers in 22 countries.
- The highest primary refractory rate was 27% with nivolumab/ipilimumab, while pembrolizumab/lenvatinib had the lowest at 10%; those classified as primary refractory only had a median survival of 7.6 months compared to 55.7 months for non-primary refractory patients.
- Significant predictors of survival for primary refractory patients included factors like prior nephrectomy and presence of bone/brain metastases, highlighting the complex
Article Synopsis
- The study investigates the effectiveness of two antibiotics, ceftazidime-avibactam (CZA) and ceftolozane-tazobactam (C/T), in treating multidrug-resistant Pseudomonas aeruginosa infections in patients on renal replacement therapy.
- A total of 45 patients were analyzed, with similar clinical cure rates for both CZA (48%) and C/T (60%), and no significant differences in outcomes such as microbiologic cure, recurrence, or 30-day mortality.
- The results suggest that both antibiotics are equally effective for clinical cure in the studied population, but further research with larger sample sizes is necessary to validate these findings.
Purpose: The aim of this study was to report the safety and tumor response rate of combined transarterial radioembolization (TARE) through the intrahepatic arteries and transarterial chemoembolization (TACE) through the extrahepatic feeding arteries (EHFA) in patients with hepatocellular carcinoma (HCC).
Methods: Patients with HCC, who had both intrahepatic and extrahepatic arterial supply visible on preinterventional multiphase CT and were treated between 2016 and 2021 with a combination of TACE and TARE on the same nodule, were retrospectively included. Epidemiological, clinical, biological, and radiological characteristics were recorded.