Publications by authors named "M Getino"
from six European countries reveals differences in profile and distribution of critical antimicrobial resistance determinants within One Health compartments, 2013 to 2020.
Euro Surveill
November 2024
BackgroundAntimicrobial resistance (AMR) is a global threat. Monitoring using an integrated One Health approach is essential to detect changes in AMR occurrence.AimWe aimed to detect AMR genes in pathogenic and commensal collected 2013-2020 within monitoring programmes and research from food animals, food (fresh retail raw meat) and humans in six European countries, to compare vertical and horizontal transmission.
View Article and Find Full Text PDFArticle Synopsis
- Carbapenemase-producing Enterobacterales (CPE), particularly those encoding imipenemase (IMP), were studied for their emergence in a London healthcare network from 2016-2019, showcasing major antibiotic resistance issues across various species.
- The research combined network analysis of patient pathways with genomic studies, identifying 84 Enterobacterales isolates, mainly from Klebsiella, Enterobacter, and E. coli, with a high prevalence of a specific plasmid linked to resistance genes.
- Findings revealed an unnoticed interspecies outbreak through plasmid sharing, emphasizing the need for enhanced investigation techniques like DNA sequencing to effectively track and manage pathogen transmission in hospital settings.
Antibiotic persistence is a phenomenon observed when genetically susceptible cells survive long-term exposure to antibiotics. These 'persisters' are an intrinsic component of bacterial populations and stem from phenotypic heterogeneity. Persistence to antibiotics is a concern for public health globally, as it increases treatment duration and can contribute to treatment failure.
View Article and Find Full Text PDFHistorically, epidemiological investigation and surveillance for bacterial antimicrobial resistance (AMR) has relied on low-resolution isolate-based phenotypic analyses undertaken at local and national reference laboratories. Genomic sequencing has the potential to provide a far more high-resolution picture of AMR evolution and transmission, and is already beginning to revolutionise how public health surveillance networks monitor and tackle bacterial AMR. However, the routine integration of genomics in surveillance pipelines still has considerable barriers to overcome.
View Article and Find Full Text PDFObjective: Increased incidence of neonatal Staphylococcus capitis bacteraemia in summer 2020, London, raised suspicion of widespread multidrug-resistant clone NRCS-A. We set out to investigate the molecular epidemiology of this clone in neonatal units (NNUs) across the UK.
Methods: We conducted whole-genome sequencing (WGS) on presumptive S.