Publications by authors named "M Georgieff"
Background: Iron deficiency affects a large proportion of pregnant women worldwide, with potentially serious consequences for perinatal and infant outcomes, but well-powered, comprehensive analyses of longitudinal iron status during pregnancy are scarce.
Objectives: This study aimed to evaluate the longitudinal changes in iron biomarkers across pregnancy and prevalence of iron deficiency in primiparous women in a high-resource setting and propose early pregnancy iron status cutoffs that predict iron deficiency in the third trimester.
Methods: In a prospective cohort of primiparous women with low-risk, singleton pregnancies in Ireland, iron [ferritin, soluble transferrin receptors (sTfR), total body iron (TBI)] and inflammatory markers (C-reactive protein, α-glycoprotein) were measured at 3 study visits: 15, 20, and 33 wk of gestation.
Article Synopsis
- Early life gut microbiomes significantly impact brain and immune system development, with probiotics suggested as a way to enhance health through microbiome modification.
- This study investigates the effects of maternal probiotic exposure during pregnancy and breastfeeding on inflammation in breastmilk, variations in maternal and infant microbiomes, and infant neurodevelopment.
- Results indicate that maternal probiotics are linked to lower breastmilk inflammation markers and changes in infant gut microbiome, as well as improved recognition memory responses in infants at 6 months old.
Article Synopsis
- Phlebotomy-induced-anemia (PIA) in neonatal rats is examined for its effects on retinopathy of prematurity (ROP), revealing that PIA may actually decrease the severity of the condition rather than worsen it as initially hypothesized.* -
- In the study, PIA resulted in a significant decrease in avascular and neovascular areas of the retina, as well as lower levels of several pro-inflammatory cytokines at key developmental stages (P15 and P20).* -
- Findings suggest that anemia has a protective effect against pathological retinal changes in ROP, influencing gene expression and molecular pathways associated with angiogenesis and inflammation, with notable differences observed based on the sex of the subjects.*
Article Synopsis
- Iron is essential for brain development, and a lack of it during key early life stages can affect neuromotor skills in infants.
- The study assessed iron levels (hemoglobin and ferritin) in 120 infants at 4 months who were exposed to prenatal anemia and examined their movement quality.
- Results showed no significant link between iron levels and movement quality, indicating that most infants had low iron levels, suggesting a need for further long-term studies rather than just one-time assessments.
Objectives: To assess sex-specific differences in the association between pre-transfusion haemoglobin values and early neurodevelopmental function.
Design: Observational follow-up of infants with birth weights <1000 g and gestational ages 22-28 weeks who were enrolled in the NICHD Neonatal Research Network Transfusion of Prematures (TOP) Trial at 19 U.S.