Publications by authors named "M Genova"
Elongator is a tRNA-modifying complex that regulates protein translation. Recently, a moonlighting function of Elongator has been identified in regulating the polarization of the microtubule cytoskeleton during asymmetric cell division. Elongator induces symmetry breaking of the anaphase midzone by selectively stabilizing microtubules on one side of the spindle, contributing to the downstream polarized segregation of cell-fate determinants, and therefore to cell fate determination.
View Article and Find Full Text PDFGestational diabetes mellitus (GDM) is considered the most common metabolic disorder of the pregnancy period. It is characterized by pancreatic beta-cell dysfunction in the setting of chronic insulin resistance. Zinc is a nutrient involved in numerous metabolic processes and shows a relationship with glycometabolic disorders and GDM.
View Article and Find Full Text PDFBackground: Copper (Cu) is a physiologically important trace element during pregnancy. The study aim is to assess the altered level of serum Cu and its association with some metabolic indexes in Gestational Diabetes Mellitus (GDM).
Methods: A total of 108 pregnant women (aged 18 - 40, second trimester) are included in the study and divided into two groups (GDM n = 54; pregnant with normal glucose tolerance (NGT), n = 54) after performing a 2-hour 75-g oral glucose tolerance test (OGTT).
Article Synopsis
- Microtubule doublets (MTDs) consist of an incomplete microtubule attached to a complete one and are found in cilia across many species, but how they form and are maintained is not well understood.
- Research identified the protein MAP9 (and its C. elegans homolog MAPH-9) as crucial for MTD assembly, which binds specifically to MTDs, influenced by tubulin modification.
- The absence of MAPH-9 leads to structural defects in MTDs and affects cilia function, indicating that MAP9/MAPH-9 is likely important in maintaining ciliary motor regulation and MTD structure in both worms and mammals.