The Beneficial Effect of IL-12 and IL-18 Transduced Dendritic Cells Stimulated with Tumor Antigens on Generation of an Antitumor Response in a Mouse Colon Carcinoma Model.

The main purpose of our study was to determine the effect of dendritic cell (DC) transduction with lentiviral vectors carrying sequences of and/or genes on the level of antitumor activity and . We examined the ability of DCs to migrate to the tumor-draining lymph nodes and infiltrate tumor tissue and to activate the local and systemic antitumor response. On the 15th day, DCs genetically modified for production of IL-12 and/or IL-18 were administered peritumorally to C57BL/6 female mice with established MC38 tumors.

[Intraoperative portography in operations for resection of pancreas neoplasms].

Since 1993 during pancreatic resection routine intraoperative portography has been employed. Thus we are able to establish infiltration engaging portal vein and its branches. Facilitating decision making about resectability of the tumor.

Results of treatment of imminent premature labour with the preparation Salbupart-POLFA.

The preparation Salbupart POLFA was used in 40 pregnant women in the treatment of imminent premature labour. The tocolytic effect of the drug was confirmed, especially in pregnancy over 32 weeks. The observed side effects, mainly in the cardiovascular system, did not require drug withdrawal, but tended towards the necessity of using symptom-alleviating drugs such as Isoptin.