Publications by authors named "M Gazal"
Eugenia uniflora fruit extract exerts neuroprotective effect on chronic unpredictable stress-induced behavioral and neurochemical changes.
J Food Biochem
October 2020
The aim of the current study was to evaluate the effect of chronic administration of Eugenia uniflora fruit extract on behavioral parameters, oxidative stress markers, and acetylcholinesterase activity in an animal model of depression, which was induced by chronic unpredictable stress (CUS). Mice were divided into six groups as follows: control/vehicle (water), control/fluoxetine (20 mg/kg), control/extract (200 mg/kg), CUS/vehicle, CUS/fluoxetine (20 mg/kg), and CUS/extract (200 mg/kg). Animals of the CUS group were exposed to a series of stressors for a period of 21 days.
View Article and Find Full Text PDFLeptin polymorphism rs3828942: risk for anxiety disorders?
Eur Arch Psychiatry Clin Neurosci
September 2021
Article Synopsis
- Leptin is a hormone involved in regulating energy balance and has been linked to psychiatric issues, showing potential antidepressant and anti-anxiety effects.
- A study with 1,067 young adults explored the connection between leptin levels, the LEP gene polymorphism (rs3828942), and anxiety disorders, considering sex differences.
- Findings revealed that while overall leptin levels and the rs3828942 genotype were not linked to anxiety disorders, the A-allele of the polymorphism was associated with a higher risk for generalized anxiety disorder (GAD) in women, indicating sex-dependent effects of leptin on anxiety.
Article Synopsis
- Genetic variants related to adenosine metabolism and its receptors are linked to psychiatric disorders like anxiety, depression, and schizophrenia.
- This study specifically focused on the ADORA2A gene's rs2298383 SNP, finding that the TT genotype significantly lowers the risk of depression compared to other genotypes.
- The TT genotype also showed an association with fewer sleep disturbances and better concentration, highlighting its potential impact on common depressive symptoms.
[Prevalence of cardiovascular risk factors in semi-rural area in Senegal].
Ann Cardiol Angeiol (Paris)
September 2018
Objectives: We aim to determine the prevalence of cardiovascular risk factors in the semi-rural population of the community of Gueoul in Senegal.
Patients And Method: This is a cross-sectional, observational and descriptive study. We conducted an exhaustive survey in 2012 according to the STEPS wise approach of the world health organization against Senegalese aged of 35 years and over who resided for at least 6 months in semi-rural area in the community of Gueoul.
Methionine and/or Methionine Sulfoxide Alter Ectoenzymes Activities in Lymphocytes and Inflammatory Parameters in Serum from Young Rats: Acute and Chronic Effects.
Cell Biochem Biophys
June 2018
In this study we investigated the effect of acute and chronic treatment with Met and/or methionine sulfoxide (MetO) on ectonucleotidases and cholinesterases activities from lymphocytes and purine derivatives compounds, C-protein reactive, interleukin-10, interleukin-6, and tumor necrosis factor-α levels in serum of young rats. Adenosine triphosphate hydrolysis was decreased in lymphocytes 1 h after treatment by MetO and Met + MetO. However, adenosine triphosphate and adenosine diphosphate hydrolysis in lymphocytes was increased in the groups MetO and Met + MetO and adenosine deaminase activity was increased in MetO 3 h after the treatment.
View Article and Find Full Text PDF