Basic Science and Pathogenesis.

Background: Subjective Cognitive Complaints (SCCs) can often precede mild cognitive impairment and dementia longitudinally. While increasingly considered an early prodromal stage of dementia, SCCs can also be a symptom of depression. Previous research found that SCCs in the absence of cognitive impairment, controlling for symptoms of depression, were moderately heritable and genetically associated with memory.

Age of menopause and dementia risk in 10,832 women from the Swedish Twin Registry.

Introduction: An earlier age of menopause (AOM) is hypothesized to increase vulnerability to the neuropathological processes of dementia which begin in midlife.

Methods: We tested this hypothesis in a sample of 10,832 women from the Swedish Twin Registry, stratified by menopause etiology. Survival models showed that a U-shaped association was present for women whose menopause occurred spontaneously.

Michael A. (Mick) Smyer (1950-2024).

Memorializes Michael A. (Mick) Smyer (1950-2024). Mick was a clinical psychologist, gerontologist, expert in mental health and aging policy, academic administrator, and climate activist.

Visual-Motor Integration (VMI) Is Also Relevant for Computer, Smartphone, and Tablet Use by Adults: Introducing the Brief Box Clicking Test.

Importance: Visual-motor integration (VMI) is typically examined in children to promote handwriting, but it may also be relevant for adults' capacity for technology use.

Objective: To examine the reliability and validity of speed of completion of the box clicking test, a web-based test of VMI.

Design: Participants in the Understanding America Study completed online surveys on a regular basis, including a very brief (less than 30 s) self-administered box clicking test.