Oligonucleotide arrays for high-throughput SNPs detection in the MHC class I genes: HLA-B as a model system.

A simple and efficient oligonucleotide array was developed to identify single nucleotide polymorphisms (SNPs) encoded within the highly polymorphic human major histocompatibility complex (MHC) using HLA-B as a model system. A total of 137 probes were designed to represent all known polymorphisms encoded in exons 2 and 3. PCR products were amplified from human genomic DNA and allowed to hybridize with the oligonucleotide array.

Rating specific chiropractic technique procedures for common low back conditions.

Objective: To rate specific chiropractic technique procedures used in the treatment of common low back conditions.

Design And Methods: A panel of chiropractors rated specific chiropractic technique procedures for their effectiveness in the treatment of common low back conditions, based on the quality of supporting evidence after systematic literature reviews and expert clinical opinion. Statements related to the rating process and clinical practice were then developed through a facilitated nominal consensus process.

Chiropractic technique procedures for specific low back conditions: characterizing the literature.

Background: Many original clinical trials and several review papers have come to the conclusion that manipulation is safe and effective for the treatment of low back pain. However, it is necessary to determine which specific types of manipulation and nonmanipulative types of chiropractic adjustive care are most effective for particular types of low back pain across both tissue-specific and functional classifications.

Objective: To characterize the quantity and quality of literature gathered for an Expert Panel that was convened to rate various specific chiropractic adjustive procedures for the treatment of common types of low back pain, drawing on the clinical expertise of the panel members and the relevant literature.

The state of the art of research on chiropractic education.

Objective: To review the current status of research on chiropractic education, including barriers to chiropractic educational research, and provide recommendations for future research activities.

Design: Narrative literature review with annotated bibliography and formal consensus statements using a modified nominal group process.

Methods: A literature search from January 1985 to May 1996.