Publications by authors named "M Garcia-Sanchez"
Toluidine blue O (TBO) is a type I-type II photosensitizer that has shown good efficacy and selectivity in antimicrobial and anticancer photodynamic therapy applications. However, its complex photochemistry with multiple photoproducts hinders its application as a photosensitizer. We have previously described the mechanism for photooxidative demethylation of TBO which in acetonitrile yields two main products: demethylated-TBO (d-TBO) and double-demethylated-TBO (dd-TBO).
View Article and Find Full Text PDFEarly rehabilitation using virtual reality-based therapy can enhance hip function and self-perception of improvement following total hip arthroplasty: A systematic review and meta-analysis.
Geriatr Nurs
December 2024
Objective: To investigate the effectiveness of virtual reality-based therapy (VRBT) after total hip arthroplasty (THA).
Methods: PubMed, SCOPUS, WOS, PEDro and CINAHL were consulted for results up to April 2024. Randomized controlled trials (RCTs) that assessed the effectiveness of VRBT (physical and cognitive videogames) in patients after THA were included.
Article Synopsis
- - The study explored how serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels could predict worsening disability in multiple sclerosis (MS), enrolling 725 patients across 13 European hospitals from 1994 to 2023.
- - Higher levels of sNfL were significantly associated with increased risks of relapse-associated worsening (RAW), progression independent of relapse activity (PIRA), and reaching an Expanded Disability Status Scale (EDSS) score of 3, while elevated sGFAP levels were linked to a higher risk of reaching the EDSS score.
- - Combining both sNfL and sGFAP levels indicated that low values represented low risk for worsening
: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a hereditary small vessel disease leading to significant morbidity and mortality. Despite advances in genetic diagnosis, the underlying pathophysiology remains incompletely understood. Proteomic studies offer insights into disease mechanisms by identifying altered protein expression patterns.
View Article and Find Full Text PDFArticle Synopsis
- The study evaluates the effectiveness and safety of the Silk Vista Baby (SVB) flow diverter for treating small cerebral aneurysms, focusing on long-term follow-up.
- Researchers analyzed data from 50 patients treated with the SVB between September 2018 and June 2021, noting a low complication rate of 8% during procedures.
- Results showed a 100% technical success rate, no re-ruptures, and a high occlusion rate of 94% at the 12-month follow-up, confirming the SVB as a safe and effective treatment option.