Essential and dual effects of Notch activity on a natural transdifferentiation event.

Cell identity can be reprogrammed, naturally or experimentally, albeit with low frequency. Why some cells, but not their neighbours, undergo a cell identity conversion remains unclear. We find that Notch signalling plays a key role to promote natural transdifferentiation in C.

Specifications and functional impact of a self-triggered grasp neuroprosthesis developed to restore prehension in hemiparetic post-stroke subjects.

Background: Stroke is the leading cause of acquired motor deficiencies in adults. Restoring prehension abilities is challenging for individuals who have not recovered active hand opening capacities after their rehabilitation. Self-triggered functional electrical stimulation applied to finger extensor muscles to restore grasping abilities in daily life is called grasp neuroprosthesis (GNP) and remains poorly accessible to the post-stroke population.

Comparisons of approaches to pelvic floor muscle training for urinary incontinence in women.

Background: Pelvic floor muscle training (PFMT) is a recommended treatment for female stress, urgency, and mixed urinary incontinence. Training varies in exercise type (pelvic floor muscles contracting with and without other muscles), dose, and delivery (e.g.

Transportation conditions of calves upon arrival at major livestock auction markets in Québec, Canada.

The objective of this cross-sectional observational study was to describe the transport conditions of calves at the time of their arrival at the 2 major livestock auction markets in the province of Québec, Canada, and to identify characteristics that affect bedding cleanliness. A particular emphasis was placed on the transport environment of young dairy calves commonly being marketed for veal production. During 4 d per auction site (n = 2 sites), 2 d in summer and 2 d in winter, the descriptive characteristics including type of transports, number of calves per transport, separation from other transported animals, as well as presence of ventilation sources (e.