Publications by authors named "M Garces-Albir"
ctDNA whole exome sequencing in pancreatic ductal adenocarcinoma unveils organ-dependent metastatic mechanisms and identifies actionable alterations in fast progressing patients.
Transl Res
September 2024
Article Synopsis
- Understanding how pancreatic ductal adenocarcinoma (PDAC) progresses and developing targeted therapies is crucial, and this study involved 80 metastatic PDAC patients divided into discovery and validation groups to examine genetic variants.
- Whole exome sequencing (WES) of tumor and plasma samples highlighted that actionable mutations were more prevalent in plasma, and associations with cellular organization pathways were found in patients with shorter survival.
- Notably, KRAS mutations in plasma were linked to worse progression free survival, while significant reductions in KRAS variant allele frequency correlated with improved outcomes similar to KRAS-negative patients, emphasizing the relevance of immune response pathways in liver metastasis.
Purpose: Three types of circular staplers can be used to perform a colorectal anastomosis: two-row (MCS), three-row (TRCS) and powered (PCS) devices. The objective of this meta-analysis has been to provide the existing evidence on which of these circular staplers would have a lower risk of presenting a leak (AL) and/or anastomotic bleeding (AB).
Methods: An in-depth search was carried out in the electronic bibliographic databases Embase, PubMed and SCOPUS.
Background: The effect of radiologic splenic vessels involvement (RSVI) on the survival of patients with pancreatic adenocarcinoma (PAC) located in the body and tail of the pancreas is controversial, and its influence on postoperative morbidity after distal pancreatectomy (DP) is unknown. This study aimed to determine the influence of RSVI on postoperative complications, overall survival (OS), and disease-free survival (DFS) in patients undergoing DP for PAC.
Methods: A multicenter retrospective study of DP was conducted at 7 hepatopancreatobiliary units between January 2008 and December 2018.
Article Synopsis
- * Data from 808 patients were analyzed, revealing that 46.9% achieved TO, with significantly lower overall complications (11.9% vs. 86%) compared to those who did not achieve TO, leading to increased major complications and mortality rates.
- * Factors enhancing the likelihood of achieving TO include treatment at specialized centers, initial surgery transfer, and conservative or surgical management, highlighting the importance of effective perioperative care in managing BDI.