Publications by authors named "M Gallicchio"
The curious case of type I interferon signaling in cancer.
Biochim Biophys Acta Rev Cancer
November 2024
Cytokines are the crucial signaling proteins that mediate the crosstalks between the cells of tumor microenvironment (TME). Interferon-1 (IFN-1) are the important cytokines that are widely known for their tumor suppressive roles comprising of cancer cell intrinsic and extrinsic mechanisms. Despite having known antitumor effects, IFN-1 are also reported to have tumor promoting functions under varying circumstances.
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- A study in Piedmont, Italy evaluated the impact of an Allergy Call Center (ACC) program established to support patients at high risk for allergic reactions during the COVID-19 vaccination campaign.
- The ACC operated from May 2021 to December 2022, receiving 15,865 calls, with only 336 patients needing further referral to the specialized unit, indicating effective management of consultations.
- Overall, the study highlighted the success of proactive screening in reducing allergy-related concerns linked to COVID-19 vaccination, streamlining the referral process for high-risk patients.
Article Synopsis
- Wiedemann-Steiner syndrome (WSS) is a rare genetic condition linked to impaired gene expression due to mutations affecting chromatin proteins, leading to various developmental issues.
- A study focused on a 10-year-old girl with signs of WSS utilized whole exome sequencing (WES) and Sanger resequencing to identify a new mutation in the KMT2A gene, which is considered likely pathogenic.
- Computational modeling of the mutated protein indicated that this change could disrupt its functionality by altering its DNA binding capabilities, providing further insight into the genetic basis of WSS.
This study addresses the widespread use of UV filters (UVFs) in cosmetic and solar products due to the negative effects of UV radiation, particularly in relation to melanoma risk. While these filters offer protection, their extensive application raises concerns about their environmental and health impacts. Organic UVFs, in particular, have been associated with endocrine disruption in aquatic species and coral reef damage.
View Article and Find Full Text PDFBackground: Several factors contribute to ischemia/reperfusion injury (IRI), including activation of the NLRP3 inflammasome and its byproducts, such as interleukin-1β (IL-1β) and caspase-1. However, NLRP3 may paradoxically exhibit cardioprotective properties. This study aimed to assess the protective effects of the novel NLRP3 inhibitor, INF195, both in vitro and ex vivo.
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