Carbon Black Functionalized with Serinol Pyrrole to Replace Silica in Elastomeric Composites.

Elastomer composites for dynamic mechanical applications with a low dissipation of energy are of great importance in view of their application in tire compounds. In this work, furnace carbon black functionalized with 2-2,5-dimethyl-1-pyrrol-1-yl-1,3-propanediol (SP) was used in place of silica in an elastomer composite based on poly(styrene-co-butadiene) from solution anionic polymerization and poly(1,4-cis-isoprene) from . The traditional coupling agent used for silica was also used for the CB/SP adduct: 3,3'-bis(triethoxysilylpropyl)tetrasulfide (TESPT).

The complement alternative pathway and hemostasis.

The complement and hemostatic systems are complex systems, and both involve enzymatic cascades, regulators, and cell components-platelets, endothelial cells, and immune cells. The two systems are ancestrally related and are defense mechanisms that limit infection by pathogens and halt bleeding at the site of vascular injury. Recent research has uncovered multiple functional interactions between complement and hemostasis.

SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet Aggregation.

Microvascular thrombosis is associated with multiorgan failure and mortality in coronavirus disease 2019 (COVID-19). Although thrombotic complications may be ascribed to the ability of SARS-CoV-2 to infect and replicate in endothelial cells, it has been poorly investigated whether, in the complexity of viral infection in the human host, specific viral elements alone can induce endothelial damage. Detection of circulating spike protein in the sera of severe COVID-19 patients was evaluated by ELISA.