Publications by authors named "M Gadelha"
Pituitary tumours (PT) are formed in the pituitary gland, a small gland situated at the base of the brain. These tumours can be categorized according to their histological origin and hormone production. In surgical series, non-functioning PT are the commonest subtype, followed by functioning somatotroph and corticotroph tumours.
View Article and Find Full Text PDFPurpose: To assess whether simultaneous normalization of late-night salivary cortisol (LNSC) and mean urinary free cortisol (mUFC) in patients with Cushing disease treated with osilodrostat is associated with better clinical outcomes than control of mUFC or LNSC alone.
Methods: Pooled data from two phase III osilodrostat studies (LINC 3 and LINC 4) were analyzed. Both comprised a 48-week core phase and an optional open-label extension.
Article Synopsis
- Acromegaly is linked to an uncertain increased risk for colorectal cancer (CRC), prompting this study to evaluate the prevalence of colonic adenomatous polyps and CRC in acromegaly patients during colonoscopies.
- The study involved 123 patients and found that the majority had non-neoplastic findings at their first colonoscopy, with a small percentage developing CRC over time; risk factors like age and smoking were significantly associated with neoplasia.
- Findings indicate that older age (specifically over 50) and smoking elevate the risk of colonic lesions, suggesting that the recommended screening age for CRC in those with acromegaly may need to be reconsidered.
Purpose: Nonfunctioning pituitary adenomas (NFPAs) are benign tumors growing in the sellar region. Total surgical excision of the lesion is recommended as the preferred treatment choice with preservation of adjacent structures. The objective is to establish a radiological score to predict the feasibility of NFPA total surgical excision.
View Article and Find Full Text PDFArticle Synopsis
- There are five subtypes of somatostatin receptors (SST1-5) that play roles in various tumors, with SST2 and SST5 being the most relevant for diagnosis and treatment.
- The article reviews the biological features of SST, emphasizing the immunohistochemical evaluation of SST2 and SST5 in growth hormone-secreting pituitary tumors as predictors of treatment response to somatostatin receptor ligands (SRL).
- There is a need for standardized immunohistochemical techniques and scoring systems for SST2 and SST5 to enhance treatment strategies for patients with somatotroph tumors.