Safety and Efficacy of the Use of pdVWF/FVIII-C in Patients with von Willebrand Disease: A Prospective, Observational, Post-Authorization Study.

IntroductionPlasma-derived von Willebrand factor containing FVIII concentrates (pdVWF/FVIII-C) are indicated as replacement therapy for patients with von Willebrand disease (VWD). This study assessed safety and efficacy associated with long-term real-world experience of the pdVWF/FVIII-C, Fanhdi, in patients with VWD.MethodsThis observational, prospective, post-authorization cohort study was conducted at five centers in Spain.

Effects of energy drinks on mental health and academic performance of university students: A systematic review and meta-analysis protocol.

Objectives: Energy drink (ED) consumption is frequently observed among higher education students and is often associated with increased concentration and academic performance. However, the purported benefits are not fully supported by scientific evidence. This protocol details methods for a systematic review and meta-analysis to evaluate the effects of ED on university students' mental health and academic performance.

Effect of non-surgical treatment in diabetes-associated periodontitis on immune/inflammatory and oxidative stress biomarkers: A pilot study.

Aims: To investigate the effects of non-surgical periodontal treatment on the levels of cytokines, sIgA, antimicrobial peptides, oxidative and antioxidative agents in comparison between patients with and without diabetes.

Methods: A case-control study that included patients (n = 45) with periodontitis who have or do not have diabetes. Cytokine concentrations in crevicular gingival fluid (GCF) and saliva were determined using LUMINEX and ELISA assays, respectively.

Acute Slice Patch-Clamp Recordings to Characterize Neural Populations in the Hippocampal Subgranular Zone.

Whole-cell patch clamp allows the evaluation of neuronal excitability and characterization of synaptic transmission. With this technique, it is possible to characterize the neuron maturation level and its integration into the hippocampal circuit. This facilitates the identification of the different stages of neural progenitor cells in the adult brain and their contribution to hippocampal function.